![]() SENTINEL SPECTRUM Chews may be offered to the dog by hand or added to a small amount of dog food. To ensure adequate absorption, always administer SENTINEL SPECTRUM Chews to dogs immediately after or in conjunction with a normal meal. Dosage Schedule Body WeightĪdminister the appropriate combination of chewables For heartworm prevention, give once monthly for at least 6 months after exposure to mosquitoes (see EFFECTIVENESS). Praziquantel is an isoquinolone anthelmintic with the chemical name 2-(Cyclohexylcarbonyl)-1,2,3,6,7,-11b-hexahydro-4H-pyrazinoisoquinolin-4-one.ĭosage and Administration: SENTINEL SPECTRUM Chews should be administerd orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, 4.55 mg/lb (10 mg/kg) lufenuron, and 2.28 mg/lb (5 mg/kg) praziquantel. ![]() Benzoylphenylurea compounds, including lufenuron, are classified as insect development inhibitors (IDIs). Lufenuron is a benzoylphenylurea derivative with the following chemical composition: N-2,6-difluorobenzamide (C 17H 8CI 2F 8N 2O 3, MW 511.15). Milbemycin oxime is classified as a macrocyclic anthelmintic. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A 4 (C 32H 45NO 7, MW 555.71) and 20% A 3 (C 31H 43NO 7, MW 541.68). Each chewable flavored tablet is formulated to provide a minimum of 0.23 mg/pound (0.5mg/kg) of milbemycin oxime, 4.55 mg/pound (10mg/kg) of lufenuron, and 2.28 mg/pound (5mg/kg) of praziquantel. Not doing so opens you up to repeat flea infestations and heartworm infections.Description: SENTINEL ® SPECTRUM ® Chews are available in four strengths in color-coded packages for oral administration to dogs and puppies according to their weight. The main thing to remember with both products is that for them to be effective, they need to be given at the recommended interval: every 4 weeks. The need to use an additional product to kill adult fleas at the start of treatment seems to be a fair price to pay for a safer, more long-term solution. Sentinel treats worms as efficiently as Trifexis, keeps flea populations under control both on your dog and their immediate environment, is half the price of its competitor, appears to be a far safer product, and is able to be used on a wider range of dogs. Trifexis will kill the fleas on your dog very quickly, but that is where it loses its edge. ![]() It seems pretty clear from both the data on these products, and from the price and customer reports that Sentinel is the clear winner here. Similarly, some Trifexis users reported some trembling, twitching, salivating, and seizures in their dogs after dosing. For Sentinel, the side effects mentioned were lethargy, vomiting, or diarrhea, which is consistent with the potential side effects listed on the data sheet. Side Effectsīoth products had some feedback about the safety of the products. There are always going to be some outliers in terms of efficacy, but the heartworm prevention/treatment claim only applies if the strict 4-weekly dosage schedule is followed. There were a number of reviews on both products reporting that their dog had tested positive for heartworm, despite being on Trifexis/Sentinel. This is something that should be made quite clear on the packaging, rather than just the fine print. There were quite a lot of complaints that Sentinel was not getting rid of fleas however, due to the way it works, it is not unexpected that pet owners won’t see an immediate elimination of fleas. Reviewers generally raved about the effectiveness of Trifexis against fleas. It aims to achieve flea control by killing adult fleas before they can reproduce, but additional environmental treatments may be needed in the cases of severe flea infestation. Spinosad acts on the nicotinic acetylcholine receptors to cause tremors, paralysis, and death in fleas, and trials have demonstrated 100% flea death within 4 hours of administration. Because the worming treatment will only kill adult worms, multiple treatments are always needed in order to eliminate eggs and larvae once they have reached adulthood. The milbemycin in Trifexis alters the permeability of invertebrate muscle cells, leading to paralysis and death of adult roundworms, hookworms, and whipworms, and is considered to be effective against heartworms after three consecutive treatments, given 4 weeks apart. ![]() It contains the insecticide Spinosad as its active ingredient against fleas, with milbemycin oxime as the anthelmintic (worm treatment). When used every 4 weeks, as prescribed, it will also treat and prevent heartworm. Trifexis is a beef-flavored, chewable tablet that kills adult fleas, roundworms, whipworms, and hookworms.
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